Colts vs. Rams prediction, odds, spread, line, start time: 2023 NFL picks, Week 4 best bets from proven model

The Los Angeles Rams (1-2) head east for a Week 4 cross-conference battle against the upstart Indianapolis Colts (2-1) on Sunday. The Rams won their season opener, but have dropped two straight including a 19-16 loss to the Cincinnati Bengals on Monday Night Football in Week 3. The Colts, on the other hand, have won two straight after losing their season opener. Indianapolis shocked the Baltimore Ravens 22-19 in overtime in Week 3. The Rams are 2-0-1 and the Colts are 2-1 against the spread in 2023.

Kickoff is scheduled for 1 p.m. ET at Lucas Oil Stadium. Indianapolis is favored by 1 point in the latest Rams vs. Colts odds, and the over/under for total points scored is 45.5. Before making any Colts vs. Rams picks, you need to see the NFL predictions and betting advice from the computer simulation model at SportsLine.

The model, which simulates every NFL game 10,000 times, is up more than $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 4 of the 2023 NFL season on an incredible 167-117 run on top-rated NFL picks that dates back to the 2017 season. It is also on an 21-9 roll on top-rated NFL picks since Week 7 of last season.

The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94 percent of CBS Sports Football Pick’em players four times during that span. Anyone who has followed it is way up.

Now, the model has set its sights on Rams vs. Colts and just locked in its picks and NFL Week 4 predictions. You can head to SportsLine now to see the model’s picks. Here are several NFL odds and betting lines for Colts vs. Rams:

  • Rams vs. Colts spread: Colts -1
  • Rams vs. Colts over/under: 45.5 points
  • Rams vs. Colts money line: Colts -111, Rams -109
  • Rams vs. Colts picks: See picks at SportsLine
  • Rams vs. Colts live stream: fubo (try for free)

Why the Rams can cover

The Rams have a proven veteran under center in Matthew Stafford. The former No. 1 overall pick battled injuries in 2022, and has gotten off to a bumpy start in 2023. Still, the 35-year-old is capable of making every throw in the book, and can carry the Rams to victory on any given Sunday.

On the other side of the ball, the Rams have a player in defensive tackle Aaron Donald, who many people consider to be the best overall player in the NFL. Donald, a three-time NFL Defensive Player of the Year, requires constant attention from opposing offensive coordinators, and can make plays from several positions. See which team to pick here.

Why the Colts can cover

The Colts will again be without All-Pro running back Jonathan Taylor, but rookie quarterback Anthony Richardson has no injury designation for this game. Veteran Zack Moss has filled in admirably for Taylor, rushing for 210 yards and a touchdown on 48 carries. Wide receiver Michael Pittman Jr. has been outstanding in the early going, catching 25 passes for 230 yards and a touchdown.

Richardson gives the Colts a dual threat at the quarterback position that will make things difficult on every level of the Rams’ defense. In two starts, Richardson, the No. 4 pick in the 2023 draft, has completed 30 of 47 passes for 279 yards, one touchdown, and one interception. He’s also rushed for 75 yards and three TDs. See which team to pick here.

How to make Rams vs. Colts picks

The model has simulated Colts vs. Rams 10,000 times and the results are in. It is leaning Under on the point total, and it also says one side of the spread is the better value. You can only see the model’s Colts vs. Rams pick at SportsLine.

So who wins Rams vs. Colts on Sunday, and which side of the spread is the better value? Visit SportsLine right now to see which side of the Colts vs. Rams spread you should be all over Sunday, all from the model on a 167-117 roll on its top-rated NFL picks, and find out.

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